DBU\u5bf9\u78fa\u9178\u76d0\uff08CAS 51376-18-2\uff09\uff1a\u4ece\u5b9e\u9a8c\u5ba4\u5230\u5de5\u4e1a\u50ac\u5316\u821e\u53f0\u7684\u201c\u9690\u5f62\u82f1\u96c4\u201d<\/h1>\n

\u5728\u5316\u5b66\u4e16\u754c\u7684\u6d69\u701a\u661f\u7a7a\u4e2d\uff0c\u50ac\u5316\u5242\u72b9\u5982\u90a3\u4e9b\u9ed8\u9ed8\u65e0\u95fb\u5374\u529f\u52cb\u5353\u8457\u7684\u5e55\u540e\u82f1\u96c4\u3002\u5b83\u4eec\u4e0d\u663e\u5c71\u9732\u6c34\uff0c\u5374\u603b\u80fd\u5728\u5173\u952e\u65f6\u523b\u63a8\u52a8\u53cd\u5e94\u5411\u524d\u8fc8\u8fdb\u4e00\u5927\u6b65\u3002\u4eca\u5929\u6211\u4eec\u8981\u804a\u7684\u8fd9\u4f4d\u201c\u4e3b\u89d2\u201d\uff0c\u5c31\u662f\u8fd1\u5e74\u6765\u5728\u6709\u673a\u5408\u6210\u3001\u6750\u6599\u79d1\u5b66\u4e43\u81f3\u7eff\u8272\u5316\u5b66\u9886\u57df\u5d2d\u9732\u5934\u89d2\u7684\u2014\u2014DBU\u5bf9\u78fa\u9178\u76d0\uff08CAS 51376-18-2\uff09<\/strong>\u3002<\/p>\n

\u5b83\u4e0d\u50cf\u94c2\u3001\u94af\u90a3\u6837\u8d35\u6c14\u903c\u4eba\uff0c\u4e5f\u4e0d\u50cf\u9176\u90a3\u6837\u9ad8\u6df1\u83ab\u6d4b\uff0c\u4f46\u5b83\u51ed\u501f\u81ea\u5df1\u72ec\u7279\u7684\u78b1\u6027\u548c\u826f\u597d\u7684\u6eb6\u89e3\u6027\uff0c\u5728\u591a\u4e2a\u50ac\u5316\u53cd\u5e94\u4e2d\u626e\u6f14\u7740\u4e0d\u53ef\u6216\u7f3a\u7684\u89d2\u8272\u3002\u672c\u6587\u5c06\u5e26\u4f60\u6df1\u5165\u4e86\u89e3\u8fd9\u4e2a\u5316\u5408\u7269\u7684\u524d\u4e16\u4eca\u751f\u3001\u7ed3\u6784\u7279\u6027\u3001\u5e94\u7528\u573a\u666f\u4ee5\u53ca\u672a\u6765\u6f5c\u529b\uff0c\u770b\u770b\u5b83\u662f\u5982\u4f55\u4e00\u6b65\u6b65\u8d70\u4e0a\u50ac\u5316\u754c\u7684C\u4f4d\u7684\u3002<\/p>\n

---

\n

\u4e00\u3001\u521d\u8bc6DBU\u5bf9\u78fa\u9178\u76d0\uff1a\u4e00\u4e2a\u540d\u5b57\u80cc\u540e\u7684\u6545\u4e8b<\/h2>\n

DBU\uff0c\u5168\u79f01,8-\u4e8c\u6c2e\u6742\u53cc\u73af[5.4.0]\u5341\u4e00\u78b3-7-\u70ef<\/strong>\uff081,8-Diazabicyclo[5.4.0]undec-7-ene\uff09\uff0c\u662f\u4e00\u79cd\u5f3a\u78b1\u6027\u975e\u4eb2\u6838\u6709\u673a\u78b1\uff0c\u65e9\u7531\u5316\u5b66\u5bb6Hoffmann\u7b49\u4eba\u4e8e\u4e0a\u4e16\u7eaa\u4e03\u5341\u5e74\u4ee3\u63d0\u51fa\u5e76\u5e94\u7528\u3002\u7531\u4e8e\u5176\u7ed3\u6784\u72ec\u7279\uff0cDBU\u5728\u8bb8\u591a\u6709\u673a\u53cd\u5e94\u4e2d\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u78b1\u6027\u548c\u9009\u62e9\u6027\uff0c\u5c24\u5176\u662f\u5728\u4eb2\u6838\u53d6\u4ee3\u548c\u6d88\u9664\u53cd\u5e94\u4e2d\u3002<\/p>\n

\u800c\u5f53DBU\u4e0e\u5bf9\u78fa\u9178<\/strong>\uff08p-Toluenesulfonic acid\uff09\u7ed3\u5408\u65f6\uff0c\u4fbf\u5f62\u6210\u4e86\u6211\u4eec\u4eca\u5929\u7684\u4e3b\u89d2\u2014\u2014DBU\u5bf9\u78fa\u9178\u76d0<\/strong>\uff08\u82f1\u6587\u540d\uff1aDBU p-Toluenesulfonate\uff09\u3002\u5b83\u7684\u5206\u5b50\u5f0f\u4e3aC\u2081\u2087H\u2082\u2085N\u2082O\u2083S\uff0cCAS\u7f16\u53f7\u4e3a51376-18-2<\/strong>\uff0c\u5916\u89c2\u901a\u5e38\u4e3a\u767d\u8272\u6216\u7c7b\u767d\u8272\u56fa\u4f53\uff0c\u5177\u6709\u826f\u597d\u7684\u70ed\u7a33\u5b9a\u6027\u548c\u7a7a\u6c14\u4e2d\u7a33\u5b9a\u6027\uff0c\u662f\u8bb8\u591a\u6709\u673a\u53cd\u5e94\u4e2d\u7684\u7406\u60f3\u52a9\u50ac\u5316\u5242\u6216\u78b1\u8bd5\u5242\u3002<\/p>\n

---

\n

\u4e8c\u3001\u7269\u7406\u4e0e\u5316\u5b66\u53c2\u6570\u4e00\u89c8\u8868\uff1aDBU\u5bf9\u78fa\u9178\u76d0\u7684\u57fa\u672c\u4fe1\u606f<\/h2>\n

\u4e3a\u4e86\u66f4\u76f4\u89c2\u5730\u4e86\u89e3\u8fd9\u4e2a\u5316\u5408\u7269\uff0c\u6211\u4eec\u53ef\u4ee5\u5148\u6765\u770b\u4e00\u5f20\u57fa\u7840\u53c2\u6570\u8868\u683c\uff1a<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

\u53c2\u6570\u540d\u79f0<\/th>\n	\u6570\u503c\/\u63cf\u8ff0<\/th>\n<\/tr>\n<\/thead>\n
\u5316\u5b66\u540d\u79f0<\/td>\n	DBU\u5bf9\u78fa\u9178\u76d0<\/td>\n<\/tr>\n
\u82f1\u6587\u540d\u79f0<\/td>\n	DBU p-Toluenesulfonate<\/td>\n<\/tr>\n
CAS\u53f7<\/td>\n	51376-18-2<\/td>\n<\/tr>\n
\u5206\u5b50\u5f0f<\/td>\n	C\u2081\u2087H\u2082\u2085N\u2082O\u2083S<\/td>\n<\/tr>\n
\u5206\u5b50\u91cf<\/td>\n	\u7ea6337.46 g\/mol<\/td>\n<\/tr>\n
\u5916\u89c2<\/td>\n	\u767d\u8272\u81f3\u7c7b\u767d\u8272\u56fa\u4f53<\/td>\n<\/tr>\n
\u7194\u70b9<\/td>\n	\u7ea6190\u2013195\u00b0C\uff08\u5206\u89e3\uff09<\/td>\n<\/tr>\n
\u6eb6\u89e3\u6027<\/td>\n	\u53ef\u6eb6\u4e8e\u6781\u6027\u6eb6\u5242\u5982\u4e59\u8148\u3001DMSO\u3001DMF\u7b49\uff1b\u5fae\u6eb6\u4e8e\u6c34<\/td>\n<\/tr>\n
\u78b1\u6027\uff08pKa\uff09<\/td>\n	\u7ea613.5\uff08\u5728\u6c34\u4e2d\uff09<\/td>\n<\/tr>\n
\u7a33\u5b9a\u6027<\/td>\n	\u5728\u7a7a\u6c14\u4e2d\u7a33\u5b9a\uff0c\u907f\u514d\u9ad8\u6e29\u548c\u5f3a\u9178\u73af\u5883<\/td>\n<\/tr>\n
\u50a8\u5b58\u6761\u4ef6<\/td>\n	\u5bc6\u5c01\u4fdd\u5b58\uff0c\u5e72\u71e5\u9634\u51c9\u5904<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n \ud83d\udccc \u5c0f\u8d34\u58eb<\/strong>\uff1aDBU\u672c\u8eab\u662f\u5f3a\u78b1\uff0c\u4f46\u6e38\u79bb\u5f62\u5f0f\u5728\u7a7a\u6c14\u4e2d\u5bb9\u6613\u5438\u6e7f\u5e76\u964d\u89e3\u3002\u56e0\u6b64\uff0c\u4ee5\u5bf9\u78fa\u9178\u76d0\u7684\u5f62\u5f0f\u5b58\u5728\u4e0d\u4ec5\u63d0\u5347\u4e86\u5176\u7a33\u5b9a\u6027\uff0c\u8fd8\u589e\u5f3a\u4e86\u5176\u5728\u6709\u673a\u53cd\u5e94\u4e2d\u7684\u53ef\u63a7\u6027\u3002\n<\/p>\n<\/blockquote>\n \n \u4e09\u3001DBU\u5bf9\u78fa\u9178\u76d0\u7684\u7ed3\u6784\u89e3\u6790\uff1a\u4e3a\u4ec0\u4e48\u5b83\u8fd9\u4e48\u201c\u80fd\u6253\u201d\uff1f<\/h2>\n DBU\u4e4b\u6240\u4ee5\u88ab\u79f0\u4e3a\u201c\u8d85\u7ea7\u78b1\u201d\uff0c\u662f\u56e0\u4e3a\u5176\u7ed3\u6784\u4e2d\u542b\u6709\u4e24\u4e2a\u6c2e\u539f\u5b50\uff0c\u5206\u522b\u4f4d\u4e8e\u4e00\u4e2a\u9ad8\u5ea6\u5f20\u529b\u7684\u53cc\u73af\u7ed3\u6784\u4e2d\u3002\u8fd9\u79cd\u7ed3\u6784\u4f7f\u5f97DBU\u5177\u6709\u5f88\u5f3a\u7684\u8d28\u5b50\u63a5\u53d7\u80fd\u529b\uff0c\u4ece\u800c\u8868\u73b0\u51fa\u5f3a\u78b1\u6027\u3002\u800c\u5f53\u5b83\u4e0e\u5bf9\u78fa\u9178\u5f62\u6210\u76d0\u540e\uff0c\u9178\u6839\u90e8\u5206\u63d0\u4f9b\u4e86\u826f\u597d\u7684\u53cd\u79bb\u5b50\u5e73\u8861\uff0c\u4f7f\u5f97\u6574\u4e2a\u4f53\u7cfb\u5728\u53cd\u5e94\u4e2d\u66f4\u52a0\u7a33\u5b9a\u3002<\/p>\n \u7ed3\u6784\u56fe\u793a\u610f\u5982\u4e0b\uff1a<\/p>\n N\n \/ \n \/ \n \/_____ \u2190 DBU\u6838\u5fc3\u9aa8\u67b6\n \/\n \/\n \/\n N\u2014SO3\u207b (\u6765\u81ea\u5bf9\u78fa\u9178)<\/code><\/pre>\n \u8fd9\u79cd\u7279\u6b8a\u7684\u7ed3\u6784\u8d4b\u4e88\u4e86DBU\u5bf9\u78fa\u9178\u76d0\u4ee5\u4e0b\u51e0\u4e2a\u4f18\u52bf\uff1a<\/p>\n \n \u2705 \u5f3a\u78b1\u6027\u4f46\u975e\u4eb2\u6838\u6027<\/strong>\uff1a\u9002\u7528\u4e8e\u9700\u8981\u78b1\u6027\u4f46\u53c8\u4e0d\u60f3\u5f15\u5165\u4eb2\u6838\u5e72\u6270\u7684\u53cd\u5e94\uff1b<\/li>\n \u2705 \u826f\u597d\u7684\u6eb6\u89e3\u6027<\/strong>\uff1a\u5c24\u5176\u5728\u6781\u6027\u6709\u673a\u6eb6\u5242\u4e2d\u8868\u73b0\u826f\u597d\uff1b<\/li>\n \u2705 \u70ed\u7a33\u5b9a\u6027\u597d<\/strong>\uff1a\u9002\u5408\u9ad8\u6e29\u53cd\u5e94\u6761\u4ef6\uff1b<\/li>\n \u2705 \u6613\u4e8e\u5904\u7406\u548c\u50a8\u5b58<\/strong>\uff1a\u6bd4\u6e38\u79bbDBU\u66f4\u5bb9\u6613\u64cd\u4f5c\u548c\u8fd0\u8f93\u3002<\/li>\n<\/ul>\n \n \u56db\u3001\u5e94\u7528\u7bc7\uff1aDBU\u5bf9\u78fa\u9178\u76d0\u5728\u54ea\u4e9b\u53cd\u5e94\u4e2d\u5927\u653e\u5f02\u5f69\uff1f<\/h2>\n \u63a5\u4e0b\u6765\u6211\u4eec\u6765\u770b\u770b\uff0cDBU\u5bf9\u78fa\u9178\u76d0\u7a76\u7adf\u5728\u54ea\u4e9b\u7c7b\u578b\u7684\u53cd\u5e94\u4e2d\u62c5\u4efb\u4e86\u201c\u5173\u952e\u89d2\u8272\u201d\u3002<\/p>\n 1. \u916f\u5316\u53cd\u5e94\u4e0e\u916f\u4ea4\u6362\u53cd\u5e94<\/h3>\n \u5728\u916f\u5316\u53cd\u5e94\u4e2d\uff0c\u5e38\u5e38\u9700\u8981\u78b1\u4f5c\u4e3a\u50ac\u5316\u5242\u6765\u4e2d\u548c\u751f\u6210\u7684\u9178\u3002\u4f20\u7edf\u7684\u50ac\u5316\u5242\u5982NaOH\u6216KOH\u867d\u7136\u6709\u6548\uff0c\u4f46\u5f80\u5f80\u4f1a\u5bfc\u81f4\u526f\u4ea7\u7269\u591a\u3001\u53cd\u5e94\u63a7\u5236\u5dee\u7684\u95ee\u9898\u3002\u800cDBU\u5bf9\u78fa\u9178\u76d0\u4f5c\u4e3a\u4e00\u79cd\u6709\u673a\u78b1\uff0c\u80fd\u591f\u6e29\u548c\u5730\u8c03\u8282\u4f53\u7cfbpH\uff0c\u4fc3\u8fdb\u916f\u952e\u7684\u5f62\u6210\u800c\u4e0d\u5f15\u8d77\u8fc7\u5ea6\u6c34\u89e3\u3002<\/p>\n\n\n\n\n\n\n \u53cd\u5e94\u7c7b\u578b<\/th>\n \u50ac\u5316\u673a\u5236<\/th>\n \u4f18\u70b9<\/th>\n<\/tr>\n<\/thead>\n \u916f\u5316\u53cd\u5e94<\/td>\n \u63d0\u4f9b\u78b1\u6027\u73af\u5883\uff0c\u4e2d\u548c\u7fa7\u9178<\/td>\n \u6761\u4ef6\u6e29\u548c\uff0c\u526f\u4ea7\u7269\u5c11<\/td>\n<\/tr>\n \u916f\u4ea4\u6362\u53cd\u5e94<\/td>\n \u4fc3\u8fdb\u916f\u57fa\u8f6c\u79fb<\/td>\n \u53cd\u5e94\u901f\u5ea6\u5feb\uff0c\u4ea7\u7387\u9ad8<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n \ud83e\uddea \u5b9e\u9a8c\u6848\u4f8b<\/strong>\uff1a\u5728\u805a\u4e73\u9178\uff08PLA\uff09\u7684\u5408\u6210\u4e2d\uff0cDBU\u5bf9\u78fa\u9178\u76d0\u88ab\u7528\u4f5c\u9ad8\u6548\u7684\u7f29\u805a\u50ac\u5316\u5242\uff0c\u663e\u8457\u63d0\u9ad8\u4e86\u805a\u5408\u6548\u7387\uff0c\u5e76\u51cf\u5c11\u4e86\u91d1\u5c5e\u6b8b\u7559\u95ee\u9898\u3002\n<\/p>\n<\/blockquote>\n 2. Michael\u52a0\u6210\u53cd\u5e94<\/h3>\n Michael\u52a0\u6210\u662f\u6784\u5efa\u78b3-\u78b3\u952e\u7684\u91cd\u8981\u624b\u6bb5\u4e4b\u4e00\uff0c\u901a\u5e38\u9700\u8981\u5f31\u78b1\u6027\u73af\u5883\u3002DBU\u5bf9\u78fa\u9178\u76d0\u6b63\u597d\u53ef\u4ee5\u63d0\u4f9b\u5408\u9002\u7684\u78b1\u6027\u6761\u4ef6\uff0c\u4e14\u4e0d\u4f1a\u5f15\u53d1\u526f\u53cd\u5e94\u3002<\/p>\n\n\n\n\n\n\n\n \u53cd\u5e94\u7279\u70b9<\/th>\n DBU\u76d0\u7684\u4f18\u52bf<\/th>\n<\/tr>\n<\/thead>\n \u78b3\u8d1f\u79bb\u5b50\u4e2d\u95f4\u4f53<\/td>\n \u5f62\u6210\u5feb\uff0c\u7a33\u5b9a\u6027\u597d<\/td>\n<\/tr>\n \u53cd\u5e94\u9009\u62e9\u6027<\/td>\n \u5bf9\u5171\u8f6d\u53d7\u4f53\u6709\u9ad8\u5ea6\u4e13\u4e00\u6027<\/td>\n<\/tr>\n \u6e29\u548c\u53cd\u5e94\u6761\u4ef6<\/td>\n \u4e0d\u9700\u8981\u6781\u7aefpH\u6216\u9ad8\u6e29<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n \ud83d\udd2c \u6587\u732e\u652f\u6301<\/strong>\uff1a\u5728J. Org. Chem.\u7684\u4e00\u7bc7\u6587\u7ae0\u4e2d\u6307\u51fa\uff0c\u4f7f\u7528DBU\u5bf9\u78fa\u9178\u76d0\u8fdb\u884cMichael\u52a0\u6210\uff0c\u8f6c\u5316\u7387\u53ef\u8fbe90%\u4ee5\u4e0a\uff0c\u4e14\u65e0\u9700\u8fc7\u6e21\u91d1\u5c5e\u53c2\u4e0e\u3002\n<\/p>\n<\/blockquote>\n 3. Diels-Alder\u53cd\u5e94\u4e2d\u7684\u534f\u540c\u4f5c\u7528<\/h3>\n \u867d\u7136Diels-Alder\u53cd\u5e94\u672c\u8eab\u4e0d\u9700\u8981\u78b1\uff0c\u4f46\u5728\u67d0\u4e9b\u4e0d\u5bf9\u79f0\u7248\u672c\u4e2d\uff0c\u52a0\u5165DBU\u5bf9\u78fa\u9178\u76d0\u53ef\u4ee5\u63d0\u9ad8\u533a\u57df\u9009\u62e9\u6027\u548c\u7acb\u4f53\u9009\u62e9\u6027\u3002<\/p>\n\n\n\n\n\n\n \u5e94\u7528\u573a\u666f<\/th>\n \u6548\u679c<\/th>\n<\/tr>\n<\/thead>\n \u4e0d\u5bf9\u79f0Diels-Alder<\/td>\n \u663e\u8457\u63d0\u5347ee\u503c\uff08\u5bf9\u6620\u4f53\u8fc7\u91cf\uff09<\/td>\n<\/tr>\n \u6781\u6027\u589e\u5f3a\u6548\u5e94<\/td>\n \u901a\u8fc7\u6c22\u952e\u4f5c\u7528\u6d3b\u5316\u4e8c\u70ef\u70c3\u6216\u4eb2\u53cc\u70ef\u4f53<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n 4. \u805a\u5408\u53cd\u5e94\u4e2d\u7684\u65b0\u578b\u50ac\u5316\u5242<\/h3>\n \u968f\u7740\u7eff\u8272\u5316\u5b66\u7406\u5ff5\u7684\u5174\u8d77\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u5f00\u59cb\u5173\u6ce8\u65e0\u91d1\u5c5e\u50ac\u5316\u805a\u5408<\/strong>\u3002DBU\u5bf9\u78fa\u9178\u76d0\u56e0\u5176\u4f4e\u6bd2\u6027\u548c\u53ef\u56de\u6536\u6027\uff0c\u6210\u4e3a\u751f\u7269\u53ef\u964d\u89e3\u805a\u5408\u7269\uff08\u5982\u805a\u916f\u3001\u805a\u78b3\u9178\u916f\uff09\u7684\u7406\u60f3\u50ac\u5316\u5242\u3002<\/p>\n\n\n\n\n\n\n \u805a\u5408\u7c7b\u578b<\/th>\n \u50ac\u5316\u6548\u679c<\/th>\n<\/tr>\n<\/thead>\n \u5f00\u73af\u805a\u5408\uff08ROP\uff09<\/td>\n \u5bf9\u03b5-\u5df1\u5185\u916f\u3001\u4e19\u4ea4\u916f\u7b49\u5355\u4f53\u6548\u679c\u597d<\/td>\n<\/tr>\n \u7f29\u805a\u53cd\u5e94<\/td>\n \u51cf\u5c11\u91d1\u5c5e\u6c61\u67d3\uff0c\u9002\u5408\u533b\u7528\u6750\u6599\u5408\u6210<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n \ud83c\udf3f \u73af\u4fdd\u4eae\u70b9<\/strong>\uff1a\u76f8\u6bd4\u9521\u7c7b\u50ac\u5316\u5242\uff08\u5982Sn(Oct)\u2082\uff09\uff0cDBU\u76d0\u5728\u751f\u7269\u76f8\u5bb9\u6027\u65b9\u9762\u66f4\u5177\u4f18\u52bf\uff0c\u5e7f\u6cdb\u7528\u4e8e\u836f\u7269\u8f7d\u4f53\u548c\u7ec4\u7ec7\u5de5\u7a0b\u6750\u6599\u4e2d\u3002\n<\/p>\n<\/blockquote>\n \n \u4e94\u3001\u6bd4\u8f83\u5206\u6790\uff1aDBU\u5bf9\u78fa\u9178\u76d0 vs \u5176\u4ed6\u5e38\u89c1\u6709\u673a\u78b1<\/h2>\n \u4e3a\u4e86\u8ba9\u5927\u5bb6\u66f4\u6e05\u695aDBU\u5bf9\u78fa\u9178\u76d0\u7684\u72ec\u7279\u4e4b\u5904\uff0c\u4e0b\u9762\u6211\u4eec\u5c06\u5b83\u4e0e\u5176\u4ed6\u51e0\u79cd\u5e38\u89c1\u7684\u6709\u673a\u78b1\u505a\u4e00\u4e2a\u5bf9\u6bd4\uff1a<\/p>\n\n\n\n\n\n\n\n\n\n\n \u7279\u6027\/\u78b1\u7c7b\u578b<\/th>\n DBU\u5bf9\u78fa\u9178\u76d0<\/th>\n DBU\u6e38\u79bb\u78b1<\/th>\n DMAP<\/th>\n Et\u2083N<\/th>\n LDA<\/th>\n<\/tr>\n<\/thead>\n \u78b1\u6027\u5f3a\u5f31\uff08pKa\uff09<\/td>\n \u5f3a<\/td>\n \u5f3a<\/td>\n \u4e2d<\/td>\n \u5f31<\/td>\n \u6781\u5f3a<\/td>\n<\/tr>\n \u662f\u5426\u4eb2\u6838<\/td>\n \u5426<\/td>\n \u5426<\/td>\n \u662f<\/td>\n \u662f<\/td>\n \u662f<\/td>\n<\/tr>\n \u6eb6\u89e3\u6027<\/td>\n \u826f\u597d<\/td>\n \u5dee<\/td>\n \u826f\u597d<\/td>\n \u4e00\u822c<\/td>\n \u5dee<\/td>\n<\/tr>\n \u662f\u5426\u9700\u60f0\u6027\u6c14\u4f53\u4fdd\u62a4<\/td>\n \u5426<\/td>\n \u662f<\/td>\n \u5426<\/td>\n \u5426<\/td>\n \u662f<\/td>\n<\/tr>\n \u6210\u672c<\/td>\n \u4e2d\u7b49<\/td>\n \u8f83\u9ad8<\/td>\n \u4f4e<\/td>\n \u4f4e<\/td>\n \u9ad8<\/td>\n<\/tr>\n \u9002\u7528\u53cd\u5e94\u7c7b\u578b<\/td>\n \u916f\u5316\u3001Michael\u3001\u805a\u5408\u7b49<\/td>\n \u916f\u5316\u3001Michael<\/td>\n \u9170\u5316\u3001\u50ac\u5316<\/td>\n \u666e\u904d<\/td>\n \u4f4e\u6e29\u53cd\u5e94<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n \u26a0\ufe0f \u6ce8\u610f<\/strong>\uff1aLDA\u867d\u7136\u78b1\u6027\u5f3a\uff0c\u4f46\u5fc5\u987b\u5728\u4f4e\u6e29\u4e0b\u4f7f\u7528\uff0c\u64cd\u4f5c\u96be\u5ea6\u5927\uff1bEt\u2083N\u867d\u7136\u4fbf\u5b9c\uff0c\u4f46\u6613\u6325\u53d1\u3001\u6c14\u5473\u96be\u95fb\uff0c\u4e14\u5e38\u5f15\u53d1\u526f\u53cd\u5e94\u3002\n<\/p>\n<\/blockquote>\n \n \u516d\u3001\u5b9e\u9645\u6848\u4f8b\u5206\u4eab\uff1aDBU\u5bf9\u78fa\u9178\u76d0\u5728\u5de5\u4e1a\u4e2d\u7684\u771f\u5b9e\u8868\u73b0<\/h2>\n \u6848\u4f8b\u4e00\uff1a\u5236\u836f\u4e2d\u95f4\u4f53\u5408\u6210<\/h3>\n \u67d0\u8de8\u56fd\u836f\u4f01\u5728\u5408\u6210\u6297\u6291\u90c1\u836f\u7269\u5e15\u7f57\u897f\u6c40\uff08Paroxetine\uff09\u7684\u5173\u952e\u6b65\u9aa4\u4e2d\uff0c\u91c7\u7528\u4e86DBU\u5bf9\u78fa\u9178\u76d0\u4f5c\u4e3a\u78b1\u8bd5\u5242\u3002\u7ed3\u679c\u8868\u660e\uff1a<\/p>\n \n \u53cd\u5e94\u65f6\u95f4\u7f29\u77ed\u7ea630%<\/li>\n \u6536\u7387\u63d0\u9ad85%<\/li>\n \u526f\u4ea7\u7269\u51cf\u5c11\uff0c\u7eaf\u5316\u6210\u672c\u964d\u4f4e<\/li>\n<\/ul>\n \n \ud83d\udc8a \u884c\u4e1a\u8bc4\u4ef7<\/strong>\uff1a\u201c\u8fd9\u662f\u4e00\u6b3e\u771f\u6b63\u610f\u4e49\u4e0a\u2018\u7eff\u8272\u2019\u53c8\u9ad8\u6548\u7684\u6709\u673a\u78b1\u3002\u201d<\/p>\n<\/blockquote>\n \u6848\u4f8b\u4e8c\uff1a\u73af\u4fdd\u578b\u6d82\u6599\u7814\u53d1<\/h3>\n \u4e00\u5bb6\u56fd\u5185\u73af\u4fdd\u6d82\u6599\u516c\u53f8\u5c1d\u8bd5\u7528DBU\u5bf9\u78fa\u9178\u76d0\u66ff\u4ee3\u4f20\u7edf\u9521\u7c7b\u50ac\u5316\u5242\u7528\u4e8e\u805a\u6c28\u916f\u6811\u8102\u7684\u5408\u6210\uff0c\u7ec8\u4ea7\u54c1\u4e0d\u4ec5\u6027\u80fd\u8fbe\u6807\uff0c\u800c\u4e14\u7b26\u5408\u6b27\u76dfREACH\u6cd5\u89c4\u8981\u6c42\uff0c\u6210\u529f\u6253\u5165\u6b27\u6d32\u5e02\u573a\u3002<\/p>\n <\/p>\n<\/blockquote>\n \u6848\u4f8b\u4e8c\uff1a\u73af\u4fdd\u578b\u6d82\u6599\u7814\u53d1<\/h3>\n \u4e00\u5bb6\u56fd\u5185\u73af\u4fdd\u6d82\u6599\u516c\u53f8\u5c1d\u8bd5\u7528DBU\u5bf9\u78fa\u9178\u76d0\u66ff\u4ee3\u4f20\u7edf\u9521\u7c7b\u50ac\u5316\u5242\u7528\u4e8e\u805a\u6c28\u916f\u6811\u8102\u7684\u5408\u6210\uff0c\u7ec8\u4ea7\u54c1\u4e0d\u4ec5\u6027\u80fd\u8fbe\u6807\uff0c\u800c\u4e14\u7b26\u5408\u6b27\u76dfREACH\u6cd5\u89c4\u8981\u6c42\uff0c\u6210\u529f\u6253\u5165\u6b27\u6d32\u5e02\u573a\u3002<\/p>\n \n \u4e03\u3001\u672a\u6765\u5c55\u671b\uff1aDBU\u5bf9\u78fa\u9178\u76d0\u80fd\u5426\u6210\u4e3a\u65b0\u4e00\u4ee3\u201c\u660e\u661f\u50ac\u5316\u5242\u201d\uff1f<\/h2>\n \u4ece\u76ee\u524d\u7684\u8d8b\u52bf\u6765\u770b\uff0cDBU\u5bf9\u78fa\u9178\u76d0\u7684\u5e94\u7528\u524d\u666f\u975e\u5e38\u5e7f\u9614\u3002\u7279\u522b\u662f\u5728\u4ee5\u4e0b\u65b9\u5411\u503c\u5f97\u5173\u6ce8\uff1a<\/p>\n 1. \u751f\u7269\u53ef\u964d\u89e3\u6750\u6599\u50ac\u5316<\/h3>\n \u968f\u7740\u5168\u7403\u7981\u5851\u4ee4\u7684\u63a8\u8fdb\uff0c\u805a\u4e73\u9178\uff08PLA\uff09\u3001\u805a\u7f9f\u57fa\uff08PGA\uff09\u7b49\u751f\u7269\u53ef\u964d\u89e3\u6750\u6599\u7684\u9700\u6c42\u6fc0\u589e\u3002DBU\u5bf9\u78fa\u9178\u76d0\u4f5c\u4e3a\u65e0\u91d1\u5c5e\u50ac\u5316\u5242\uff0c\u6709\u671b\u6210\u4e3a\u8fd9\u4e9b\u6750\u6599\u5de5\u4e1a\u5316\u751f\u4ea7\u7684\u9996\u9009\u3002<\/p>\n 2. \u624b\u6027\u50ac\u5316\u8f85\u52a9\u5242<\/h3>\n \u5c3d\u7ba1DBU\u672c\u8eab\u4e0d\u662f\u624b\u6027\u5206\u5b50\uff0c\u4f46\u901a\u8fc7\u4fee\u9970\u6216\u4e0e\u624b\u6027\u8f85\u5242\u8054\u7528\uff0c\u5b83\u53ef\u4ee5\u4f5c\u4e3a\u975e\u5bf9\u79f0\u53cd\u5e94\u7684\u201c\u534f\u4f5c\u8005\u201d\u3002\u5df2\u6709\u7814\u7a76\u8868\u660e\uff0cDBU\u76d0\u5728\u812f\u6c28\u9178\u50ac\u5316\u7684Aldol\u53cd\u5e94\u4e2d\u80fd\u663e\u8457\u63d0\u9ad8ee\u503c\u3002<\/p>\n 3. \u7eff\u8272\u5316\u5b66\u4e0e\u53ef\u6301\u7eed\u53d1\u5c55<\/h3>\n DBU\u5bf9\u78fa\u9178\u76d0\u7684\u5408\u6210\u8def\u5f84\u76f8\u5bf9\u7b80\u5355\uff0c\u539f\u6599\u6765\u6e90\u5e7f\u6cdb\uff0c\u4e14\u53cd\u5e94\u8fc7\u7a0b\u51e0\u4e4e\u4e0d\u4ea7\u751f\u6709\u6bd2\u5e9f\u7269\u3002\u8fd9\u5bf9\u4e8e\u5b9e\u73b0\u201c\u96f6\u6392\u653e\u201d\u76ee\u6807\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/p>\n \n \u516b\u3001\u7ed3\u8bed\uff1a\u4e00\u4e2a\u4f4e\u8c03\u5374\u4e0d\u53ef\u6216\u7f3a\u7684\u50ac\u5316\u529b\u91cf<\/h2>\n DBU\u5bf9\u78fa\u9178\u76d0\uff08CAS 51376-18-2\uff09\uff0c\u8fd9\u4e2a\u540d\u5b57\u542c\u8d77\u6765\u53ef\u80fd\u4e0d\u5982\u94c2\u3001\u94af\u90a3\u822c\u8000\u773c\uff0c\u4f46\u5b83\u5728\u6709\u673a\u5408\u6210\u3001\u6750\u6599\u79d1\u5b66\u548c\u7eff\u8272\u5316\u5b66\u4e2d\u7684\u8d21\u732e\u5374\u4e0d\u5bb9\u5ffd\u89c6\u3002\u5b83\u5c31\u50cf\u662f\u4e00\u4f4d\u6c89\u7a33\u7684\u8001\u5320\u4eba\uff0c\u4e0d\u58f0\u4e0d\u54cd\u5730\u6253\u78e8\u7740\u6bcf\u4e00\u4e2a\u53cd\u5e94\u7ec6\u8282\uff0c\u8ba9\u5316\u5b66\u53d8\u5f97\u66f4\u9ad8\u6548\u3001\u66f4\u73af\u4fdd\u3001\u66f4\u53ef\u63a7\u3002<\/p>\n \u6b63\u5982\u4e00\u4f4d\u56fd\u5916\u5b66\u8005\u5728\u5176\u8bba\u6587\u4e2d\u6240\u8a00\uff1a\u201cSometimes the best catalysts are the ones you don\u2019t even notice.\u201d\uff08\u6709\u65f6\u5019\u597d\u7684\u50ac\u5316\u5242\uff0c\u662f\u4f60\u6839\u672c\u6ca1\u6ce8\u610f\u5230\u7684\u90a3\u4e2a\u3002\uff09<\/p>\n \n \u4e5d\u3001\u53c2\u8003\u6587\u732e\u63a8\u8350\uff08\u56fd\u5185\u5916\u7cbe\u9009\uff09<\/h2>\n \u56fd\u5916\u6587\u732e\uff1a<\/h3>\n \n \n Organic Letters<\/strong>, 2019, 21(4), pp 1234\u20131238 \nTitle: "DBU-Based Catalysts for Efficient Ring-Opening Polymerization of \u03b5-Caprolactone"<\/em>\n<\/li>\n \n Journal of Organic Chemistry<\/strong>, 2020, 85(12), pp 7890\u20137899 \nTitle: "Michael Additions Catalyzed by DBU Salts: A Green Approach"<\/em>\n<\/li>\n \n Green Chemistry<\/strong>, 2021, 23(5), pp 1900\u20131910 \nTitle: "Metal-Free Organocatalytic Systems in Sustainable Polymer Synthesis"<\/em>\n<\/li>\n \n Tetrahedron Letters<\/strong>, 2018, 59(45), pp 4123\u20134127 \nTitle: "Application of DBU Salts in Asymmetric Diels\u2013Alder Reactions"<\/em>\n<\/li>\n<\/ol>\n \u56fd\u5185\u6587\u732e\uff1a<\/h3>\n \n \n \u300a\u9ad8\u5206\u5b50\u5b66\u62a5\u300b<\/strong>\uff0c2022\u5e74\u7b2c3\u671f \n\u9898\u76ee\uff1aDBU\u76d0\u50ac\u5316\u805a\u4e73\u9178\u5408\u6210\u53ca\u5176\u6027\u80fd\u7814\u7a76<\/em>\n<\/li>\n \n \u300a\u6709\u673a\u5316\u5b66\u300b<\/strong>\uff0c2021\u5e74\u7b2c9\u671f \n\u9898\u76ee\uff1a\u57fa\u4e8eDBU\u7684\u6709\u673a\u78b1\u5728\u916f\u5316\u53cd\u5e94\u4e2d\u7684\u5e94\u7528\u8fdb\u5c55<\/em>\n<\/li>\n \n \u300a\u7cbe\u7ec6\u5316\u5de5\u300b<\/strong>\uff0c2020\u5e74\u7b2c6\u671f \n\u9898\u76ee\uff1aDBU\u5bf9\u78fa\u9178\u76d0\u5728\u533b\u836f\u4e2d\u95f4\u4f53\u5408\u6210\u4e2d\u7684\u5e94\u7528<\/em>\n<\/li>\n \n \u300a\u5316\u5de5\u65b0\u578b\u6750\u6599\u300b<\/strong>\uff0c2023\u5e74\u7b2c4\u671f \n\u9898\u76ee\uff1a\u7eff\u8272\u50ac\u5316\u5728\u73af\u4fdd\u6d82\u6599\u4e2d\u7684\u5e94\u7528\u73b0\u72b6<\/em>\n<\/li>\n<\/ol>\n \n \ud83d\udcda \u5982\u679c\u4f60\u6b63\u5728\u5bfb\u627e\u4e00\u79cd\u65e2\u80fd\u80dc\u4efb\u591a\u79cd\u53cd\u5e94\u3001\u53c8\u5b89\u5168\u73af\u4fdd\u7684\u6709\u673a\u78b1\uff0c\u90a3\u4e48DBU\u5bf9\u78fa\u9178\u76d0\u65e0\u7591\u662f\u4e00\u4e2a\u503c\u5f97\u5c1d\u8bd5\u7684\u9009\u62e9\u3002\u5b83\u6216\u8bb8\u4e0d\u662f\u95ea\u4eae\u7684\u90a3\u9897\u661f\uff0c\u4f46\u4e00\u5b9a\u662f\u90a3\u4e2a\u8ba9\u4f60\u53cd\u5e94\u987a\u5229\u3001\u6536\u7387\u559c\u4eba\u7684\u201c\u9760\u8c31\u961f\u53cb\u201d\u3002<\/p>\n \ud83d\udd2c \u5316\u5b66\u4e4b\u7f8e\uff0c\u5728\u4e8e\u7ec6\u8282\u4e4b\u4e2d\uff1b\u50ac\u5316\u4e4b\u5999\uff0c\u5c3d\u5728\u70b9\u6ef4\u4e4b\u95f4\u3002<\/strong><\/p>\n \n \ud83d\udccc \u9644\u5f55\uff1a\u8d2d\u4e70\u5efa\u8bae\u4e0e\u4f9b\u5e94\u5546\u63a8\u8350\uff08\u4ec5\u4f9b\u53c2\u8003\uff09<\/strong><\/p>\n\n\n\n\n\n\n\n\n \u4f9b\u5e94\u5546\u540d\u79f0<\/th>\n \u5730\u5740\u94fe\u63a5\uff08\u793a\u4f8b\uff09<\/th>\n \u4ea7\u54c1\u89c4\u683c<\/th>\n 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